Cannabinol (CBN) is a mildly psychoactive cannabinoid formed as THC ages and oxidizes. Known as the “sleep molecule,” CBN is rare in fresh cannabis but accumulates in aged material. It has gained attention for its calming, sedative properties and its unique role within the entourage effect, contributing to the restful and restorative potential of the plant.
CBN’s molecular formula is C₂₁H₂₆O₂, with a molar mass of approximately 310.43 g/mol. Structurally, CBN is fully aromatized compared to THC, featuring two additional double bonds within its core. It is classified as a neutral cannabinoid and typically appears as a colorless crystal or yellowish oil, with a boiling point around 185 °C.
CBN exhibits low affinity for CB₁ receptors and moderate binding to CB₂ receptors, contributing to its mild psychoactivity. It also interacts with TRPV2 ion channels. These mechanisms underlie its sedative, anti-inflammatory, and neuroprotective effects. CBN may also enhance appetite and modulate pain perception.
CBN is under investigation for its potential in sleep induction, chronic pain relief, appetite stimulation, and anti-inflammatory therapy. While not yet an approved medication, it is found in full-spectrum cannabis extracts and is valued for its supportive effects, especially in products designed to aid sleep.
CBN is generally well-tolerated and non-intoxicating at typical doses, but its sedative impact is often mild unless combined with other cannabinoids or terpenes. Availability in products can be variable, and clinical research remains limited compared to THC and CBD.
🛌 Sleep — Calm — Entropy
🔄 Transition — The wisdom of aging
Emerging research explores CBN’s potential in neurodegenerative disease, antibacterial applications, and as a co-therapeutic in cannabinoid-based sleep and pain solutions.
CBN is the gentle, ancient wisdom within cannabis—embodying rest, calm, and transformation. Its understated action complements the plant’s broader effects and highlights the complexity and depth of the cannabis pharmacological spectrum.
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