Cannabitriol (CBT) is a rare and mysterious cannabinoid present only in trace amounts within cannabis plants. Recognized for its diverse isomeric forms, CBT’s subtle existence hints at a hidden layer of the cannabis matrix. Although only recently isolated and identified, its unique structure and potential biological actions are capturing the curiosity of cannabinoid researchers worldwide.
CBT is not a single compound but a family of isomers, most commonly represented by CBT-C (C₂₁H₃₀O₄), with a molar mass of approximately 346.46 g/mol. Its structure is characterized by multiple hydroxyl groups and is formed through the oxidative modification of other cannabinoids. CBT is classified as a neutral cannabinoid and generally appears as a colorless oil, with an estimated boiling point of 190 °C.
CBT shows very low binding affinity for CB₁ and CB₂ cannabinoid receptors. Early research points to possible interactions with serotonin receptors and neural pathways, suggesting potential neuroprotective and antioxidant effects. However, most pharmacological actions of CBT remain uncharted, making it a promising but enigmatic subject in the cannabinoid field.
There are currently no established clinical uses for CBT. Preclinical research is investigating its anticonvulsant, neuroprotective, and anti-inflammatory properties. The rarity and low abundance of CBT in cannabis make it a frontier molecule for future therapeutic exploration, particularly in neurological and oxidative stress disorders.
CBT’s natural levels are extremely low, making standardized extraction and research difficult. Its safety, toxicity, and comprehensive biological effects are largely unknown. As with many rare cannabinoids, much of the available information is speculative or derived from in vitro studies.
🫧 Shadow Compound — Polyhydroxy Pioneer — Unwritten Story
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CBT’s research frontiers include neuroprotection, anticonvulsant action, and modulation of neurotransmitter systems. Scientists are also exploring its potential in oxidative stress regulation, anti-inflammatory pathways, and as a novel target for brain health and resilience.
Cannabitriol stands as a symbol of hidden potential and untapped intelligence within the cannabis plant. Though only beginning to reveal its secrets, CBT may one day expand the boundaries of cannabinoid-based medicine with new neuroprotective and restorative strategies.
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